This guidance describes a systematic approach called the “Evidence to Recommendation Process” (henceforth called “EtRProcess”) for use by national immunization technical advisory groups (NITAGs). The process described is based on the EtR Process used by the WHO Strategic Advisory Groups of Experts on Immunization (SAGE) and other long-functioning NITAGs, but has been adapted to fit the level of maturity of recently established NITAGs, which often face limited human and financial resources. Conducting a systematic literature review to collect evidence on the benefits and harms of an intervention is intentionally not included in the EtR Process described in this guidance. Instead NITAGs with limited time and resources are encouraged to use systematic literature reviews conducted by WHO SAGE or other long-functioning NITAGs as an evidence resource.