Many adolescent sexual and reproductive health (ASRH) projects encounter and address policy and programmatic challenges, and in doing so, learn valuable lessons. Since careful documentation and rigorous evaluation are the exception rather than the norm, though, the lessons from these efforts are not extracted and placed in the public arena. Post-project evaluations thus have a role to complement prospective studies for new or follow-on projects. However, there is a lack of guidance and literature on post-project evaluations, and technical guidance from funding agencies for conducting post-project evaluation is rare. To begin to bridge this gap more formally, the World Health Organization (WHO) developed this practical guidance for conducting post-project evaluations of ASRH projects.