This document is meant to provide guidance to all staff of the World Health Organization (WHO), of Member States and in partner organizations who need to create, commission, fund, broker or apply evidence. This process is composed of two distinct but interacting components:
• evidence creation, represented as a funnel, moving from an overwhelming number of primary studies or data of variable quality towards a more concise, clear and user-friendly packaging of the research evidence (such as in guidelines, evidence briefs for policy [EBPs], and health technology assessments [HTAs]); and
• evidence application, represented through the policy/action cycle, outlining the steps needed for evidence to be applied in policy or practice.
This guidance, and associated repository of tools, provides WHO staff and partners with a set of methods and tools for evidence-informed decision-making (EIDM) across the clinical (or practice), public health and health system fields.
